何建波 博士，男，生于1986年，教授（三级）、博士生导师，九三社员，西南大学发育生物学与再生医学研究中心副主任；淡水鱼类资源与生殖发育教育部重点实验室副主任，国家优秀青年科学基金，重庆市杰出青年科学基金获得者。主要研究方向是利用斑马鱼和小鼠为模式动物探索并揭示肝脏受损再生的细胞和分子机制，取得以下发现：1）率先在体内发现肝脏重度损伤后胆管细胞向肝细胞转分化是新生肝细胞的主要细胞来源，解决了长久以来对胆管细胞是否参与肝脏再生的争论，该成果一经发表便引起业界广泛关注，开启了胆管细胞转分化在肝脏再生研究中的热点研究方向，引用200余次；2）在调控胆管细胞转分化的机制方面，发现Dnmt1和Rngtt等重要因子及mTORC1信号通路作为调控胆管细胞转分化的开关，系列成果填补了肝脏再生起始调控的空白；揭示维持新生肝细胞增殖和存活的重要调控靶标 (Nbn和Tel2)，深入揭示调控胆管细胞转分化的重要因子对于晚期肝病临床治疗具有重要意义；3）建立多个胆管损伤再生动物模型，发现肝外胆管是肝内胆管再生的重要细胞来源，进一步揭示胆囊具有调控肝内胆管再生的新功能，表明我们对胆囊功能的认知并不完整，胆囊也并非想所想象的那样属于“不重要器官”，提示未来对患者进行胆囊切除手术前须更严肃地评估，避免非必要的胆囊切除。以第一作者或通讯作者在Nature Cell Biology, Gastroenterology, Hepatology (2019, 2023), Nature Protocols, Cell Reports, NPJ Regenerative Medicine (2022, 2023), PLoS Genetics, iScience, J Biol Chem 等国际主流期刊发表论文十余篇。2021年获得国家优青，2023年获得重庆市杰青；近年来获得了国家重点研发计划项目课题（2017、2019）、科技部“863”计划课题、基金委面上项目（2019、2025）、青年项目等资助。荣获重庆市自然科学奖一等奖（2020；排名第二），蔡司斑马鱼科学研究奖-优秀青年学者奖（2024），重庆市学术技术带头人（2024），西南大学“优秀教师”，西南大学“十三五”科研工作先进个人和重庆市优秀博士学位论文等荣誉称号。现担任淡水鱼类资源与生殖发育教育部重点实验室副主任，重庆市细胞生物学学会副理事长，中国细胞生物学学会理事，中国细胞生物学学会青年工作委员会委员等职务。

主要论著：

1)He Jianbo^#; Li Shuang^#; Yang Zhuolin; Ma Jianlong; Qian Chuanfang; Huang Zhuofu; Li Linke; Yang Yun; Chen Jingying; Sun Yunfan; Zhao Tianyu; Luo Lingfei*; Gallbladder-derived retinoic acid signalling drives reconstruction of the damaged intrahepatic biliary ducts, Nature Cell Biology, 2025, 27:39-47. (IF=17.3)

2)Jingying Chen,Jing Ding,Yongyu Li,Fujuan Feng,Yuhang Xu,Tao Wang,Jianbo He,Jing Cang,Lingfei Luo*. (2024). Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3. Nature Communications, 15(1):5986. (IF=14.7)

3)Cai Pengcheng^#, Ni Rui^#, Lv mengzhu^#, Zhao Jieqiong, He Jianbo, Luo Lingfei*. (2023). VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis. Cell Reports, 42(9):113028 (IF=9.42)

4)Ma Jianlong^#, Yang Zhuolin^#, Huang Zhuofu, Li Linke, Huang Jingliang, Chen Jingying, Ni Rui, Luo Lingfei, He Jianbo*. (2023). Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology, 78:167-178. (IF=17.425)

5)Wei Xiangyong^#, Tan Xinmiao^#, Chen Qi^#, Jiang Yan, Wu Guozhen, Ma Xue, Fu Jialong, Li Yongyu, Gang Kai, Yang Qifen, Ni Rui, He Jianbo, Luo Lingfei*. (2023). Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish. Cell Reports, 25;42(7):112660. (IF=9.42)

6)Song Jingmei^#, Ma Jianlong^#, Liu Xing, Huang Zhuofu, Li Linke, Luo Lingfei, Ni Rui*, He Jianbo*. (2023). The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway. npj regenerative medicine 8: 20. (IF=14.40)

7)Ma Jianlong^#, Gu Yayun^#, Liu Juanjuan^#, Song Jingmei^#, Zhou Tao, Jiang Min, Wen Yang, Guo Xuejiang, Zhou Zuomin, Sha Jiahao, He jianbo, Hu Zhibin, Luo Lingfei, Liu Mingxi*. (2022). Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish. Cell Mol Life Sci 80, 1. (IF=9.24)

8)Chen jingying, He Jianbo, Luo Lingfei*. (2022). Brain vascular damage-induced lymphatic ingrowth is directed by Cxcl12b/Cxcr4a. Development 149, dev200729. (IF=6.82)

9)Zhang Junren^#, Zhou yang^#, Li Shuang, Mo Dashuang, Ni rui, Yang Qifen, He Jianbo*, Luo Lingfei*. (2022). Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration. Cell Reports 39, 110596. (IF=9.42)

10)He Jianbo^#, Zhou Yang^#, Qian Chuanfang, Wang Danyang, Yang Zhuolin, Huang Zhuofu, Sun Junhui, Yang Qifen, Chen Jingying, Luo Lingfei*. (2022). DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration. npj regenerative medicine 7: 21. (IF=14.40)

11)Zhang Wenfeng, Wu Chuan, Ni Rui, Yang Qifen, Luo Lingfei*, He Jianbo*. (2021). Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics 17, e1009980. (IF=5.92)

12)Chen Jingying, Li Xiuhua, Ni Rui, Yang Qifen, He Jianbo, Luo Lingfei*. (2021). Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell 49, 697-710.e695. (IF=12.27)

13)Cai Pengcheng, Mao Xiaoyu, Zhao Jieqiong, Nie Li, Jiang Yan, Yang Qifen, Ni Rui, He Jianbo, Luo Lingfei*. (2021). Farnesoid X Receptor is Required for the Redifferentiation of Bi-potential Progenitor Cells during Biliary-Mediated Zebrafish Liver Regeneration. Hepatology 74, 3345-3361. (IF=17.425)

14)Zhang Wenfeng, Chen Jingying, Ni Rui, Yang Qifen, and Luo Lingfei*, He Jianbo*. (2021). Contributions of biliary epithelial cells to hepatocyte homeostasis and regeneration in zebrafish. iScience 24: 102142. (IF=5.458)

15)He Jianbo^#, Mo Dashuang^#, Chen Jingying, and Luo Lingfei*. (2020). Combined whole-mount fluorescence in situ hybridization and antibody staining in zebrafish embryos and larvae. Nature Protocols 15, 3361-3379. (IF=13.491)

16)Hu Liang, Li Hongyan, Chi Zhiping, and He Jianbo*. (2020). Loss of the RNA-binding protein Rbm15 disrupts liver maturation in zebrafish. Journal of Biological Chemistry 295, 11466-11472 (IF=5.157)

17)He Jianbo, Chen Jingying, Wei Xiangyong, Leng Hui, Mu Hongliang, Cai Pengcheng, and Luo Lingfei*. (2019). mTORC1 Signaling is Required for the Dedifferentiation from Biliary Cell to Bi-potential Progenitor Cell in Zebrafish Liver Regeneration. Hepatology. 70, 2092-2106. (IF=17.425)

18)He Jianbo, Lu Huiqiang, Zou Qingliang, and Luo Lingfei*. (2014). Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish. Gastroenterology 146, 789-800 e788. (IF=22.682)

19)Chen Jingying, He Jianbo, Ni Rui, Yang Qifen, Zhang Yaoguang, and Luo Lingfei*. (2019). Cerebrovascular Injuries Induce Lymphatic Invasion into Brain Parenchyma to Guide Vascular Regeneration in Zebrafish. Developmental Cell 49, 697-710.e5. (IF=12.27)

20)Zhong Yadong, Huang Wei, Du Jiang, Wang Zekun, He Jianbo, and Luo Lingfei*. (2019). Improved Tol2-mediated enhancer trap identifies weakly expressed genes during liver and beta cell development and regeneration in zebrafish. Journal of Biological Chemistry 294, 932-940. (IF=5.157)

21)Zou Qingliang, Gang Kai, Yang Qifen, Liu Xiaolin, Tang Xuemei, Lu Huiqiang, He Jianbo, and Luo Lingfei*. (2018). The CCCH-type zinc finger transcription factor Zc3h8 represses NF-kB-mediated inflammation in digestive organs in zebrafish. Journal of Biological Chemistry 293, 11971-11983. (IF=5.157)

22)He Jia^#, Yang Yun^#, Zhang Junren, Chen Jinzi, Wei Xiangyong, He Jianbo, and Luo Lingfei*. (2017). Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish. Journal of Genetics and Genomics 44, 567-576. (IF=4.275)

23)Zhan Yandong^#, Huang Youkui^#, Chen Jingying^#, Cao Zigang, He Jianbo, Zhang Jingjing, Huang Honghui, Ruan Hua, Luo Lingfei*, and Li Li*. (2018). Caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish. Journal of Genetics and Genomics 45, 315-324. (IF=5.157)

24)Chen Jingying, He Jianbo, Li Li, Yang Deqin*, and Luo Lingfei*. (2016). Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Scientific Reports 6: 26608. (IF=4.379)

25)Zhang Ling & He Jianbo*. (2018). Progress of GATA6 in liver development. Yichuan 40, 22-32.

*：通讯作者或共同通讯；#：共同第一作者

实验室欢迎有志于从事器官再生研究的学生加入（包括保送生和调剂生）

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