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何建波
发布时间： 2022-04-22  作者：   来源：   浏览次数：


何建波，男，1986年6月出生，国家优秀青年科学基金，重庆市杰出青年科学基金获得者。四川米易人，九三社员。2005-2014年在西南大学获得学士和博士学位，2014年至2021年任西南大学生命科学学院副研究员，2021年至今任西南大学发育生物学与再生医学研究中心教授，发育生物学与再生医学研究中心副主任。主要研究方向是利用斑马鱼和小鼠探索并揭示肝脏受损再生的细胞和分子机制。主持并参与多项国家级和省部级课题研究，集中探讨肝脏重度受损后再生的细胞和分子机制，首次在体内发现肝脏再生的新的重要来源-成熟的胆管细胞转分化，解决了长久以来对胆管细胞是否参与肝脏再生的争论，该发现一经发表后在业界引起广泛关注，引用率上百次。近期，又发现Dnmt1、Nbn、Rngtt和Tel2等重要因子及mTORC1信号通路作为调控胆管细胞转分化的开关，系列成果填补了肝脏再生起始调控的空白。以第一作者或通讯作者在Gastroenterology, Hepatology（2019,2023）, Nature Protocols, Cell Reports, NPJ Regenerative Medicine（2022,2023）, PLoS Genetics, iScience, J Biol Chem 等国际主流期刊发表论文十余篇。2021年获得“国家优青”，2023年获得“重庆市杰青”；近年来获得了国家重点研发计划项目课题（2017、2019）、科技部“863”计划课题、基金委面上项目、青年项目等资助。荣获2019年度重庆市自然科学奖一等奖（排名第二），西南大学“十三五”科研工作先进个人和重庆市优秀博士学位论文。担任重庆市细胞生物学会副理事长，中国细胞生物学学会理事，中国细胞生物学学会青年工作委员会委员，斑马鱼学会青年委员会委员等职务。

主要论著：

1) Cai Pengcheng#, Ni Rui#, Lv mengzhu#, Zhao Jieqiong, He Jianbo, Luo Lingfei*. (2023). VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis. Cell Reports, 42(9):113028 (IF=9.42)

2) Ma Jianlong#, Yang Zhuolin#, Huang Zhuofu, Li Linke, Huang Jingliang, Chen Jingying, Ni Rui, Luo Lingfei, He Jianbo*. (2023). Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology, 78:167-178. (IF=17.425)

3) Song Jingmei#, Ma Jianlong#, Liu Xing, Huang Zhuofu, Li Linke, Luo Lingfei, Ni Rui*, He Jianbo*. (2023). The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway. npj regenerative medicine 8: 20. (IF=14.40)

4) Ma Jianlong#, Gu Yayun#, Liu Juanjuan#, Song Jingmei#, Zhou Tao, Jiang Min, Wen Yang, Guo Xuejiang, Zhou Zuomin, Sha Jiahao, He jianbo, Hu Zhibin, Luo Lingfei, Liu Mingxi*. (2022). Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish. Cell Mol Life Sci 80, 1. (IF=9.24)

5) Chen jingying, He Jianbo, Luo Lingfei*. (2022). Brain vascular damage-induced lymphatic ingrowth is directed by Cxcl12b/Cxcr4a. Development 149, dev200729. (IF=6.82)

6) Zhang Junren#, Zhou yang#, Li Shuang, Mo Dashuang, Ni rui, Yang Qifen, He Jianbo*, Luo Lingfei*. (2022). Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration. Cell Reports 39, 110596. (IF=9.42)

7) He Jianbo#, Zhou Yang#, Qian Chuanfang, Wang Danyang, Yang Zhuolin, Huang Zhuofu, Sun Junhui, Yang Qifen, Chen Jingying, Luo Lingfei*. (2022). DNA methylation maintenance at the p53 locus initiates biliary-mediated liver regeneration. npj regenerative medicine 7: 21. (IF=14.40)

8) Zhang Wenfeng, Wu Chuan, Ni Rui, Yang Qifen, Luo Lingfei*, He Jianbo*. (2021). Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics 17, e1009980. (IF=5.92)

9) Chen Jingying, Li Xiuhua, Ni Rui, Yang Qifen, He Jianbo, Luo Lingfei*. (2021). Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell 49, 697-710.e695. (IF=12.27)

10) Cai Pengcheng, Mao Xiaoyu, Zhao Jieqiong, Nie Li, Jiang Yan, Yang Qifen, Ni Rui, He Jianbo, Luo Lingfei*. (2021). Farnesoid X Receptor is Required for the Redifferentiation of Bi-potential Progenitor Cells during Biliary-Mediated Zebrafish Liver Regeneration. Hepatology 74, 3345-3361. (IF=17.425)

11) Zhang Wenfeng, Chen Jingying, Ni Rui, Yang Qifen, and Luo Lingfei*, He Jianbo*. (2021). Contributions of biliary epithelial cells to hepatocyte homeostasis and regeneration in zebrafish. iScience 24: 102142. (IF=5.458)

12) He Jianbo#, Mo Dashuang#, Chen Jingying, and Luo Lingfei*. (2020). Combined whole-mount fluorescence in situ hybridization and antibody staining in zebrafish embryos and larvae. Nature Protocols 15, 3361-3379. (IF=13.491)

13) Hu Liang, Li Hongyan, Chi Zhiping, and He Jianbo*. (2020). Loss of the RNA-binding protein Rbm15 disrupts liver maturation in zebrafish. Journal of Biological Chemistry 295, 11466-11472 (IF=5.157)

14) He Jianbo, Chen Jingying, Wei Xiangyong, Leng Hui, Mu Hongliang, Cai Pengcheng, and Luo Lingfei*. (2019). mTORC1 Signaling is Required for the Dedifferentiation from Biliary Cell to Bi-potential Progenitor Cell in Zebrafish Liver Regeneration. Hepatology. 70, 2092-2106. (IF=17.425)

15) He Jianbo, Lu Huiqiang, Zou Qingliang, and Luo Lingfei*. (2014). Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish. Gastroenterology 146, 789-800 e788. (IF=22.682)

16) Chen Jingying, He Jianbo, Ni Rui, Yang Qifen, Zhang Yaoguang, and Luo Lingfei*. (2019). Cerebrovascular Injuries Induce Lymphatic Invasion into Brain Parenchyma to Guide Vascular Regeneration in Zebrafish. Developmental Cell 49, 697-710.e5. (IF=12.27)

17) Zhong Yadong, Huang Wei, Du Jiang, Wang Zekun, He Jianbo, and Luo Lingfei*. (2019). Improved Tol2-mediated enhancer trap identifies weakly expressed genes during liver and beta cell development and regeneration in zebrafish. Journal of Biological Chemistry 294, 932-940. (IF=5.157)

18) Zou Qingliang, Gang Kai, Yang Qifen, Liu Xiaolin, Tang Xuemei, Lu Huiqiang, He Jianbo, and Luo Lingfei*. (2018). The CCCH-type zinc finger transcription factor Zc3h8 represses NF-kB-mediated inflammation in digestive organs in zebrafish. Journal of Biological Chemistry 293, 11971-11983. (IF=5.157)

19) He Jia#, Yang Yun#, Zhang Junren, Chen Jinzi, Wei Xiangyong, He Jianbo, and Luo Lingfei*. (2017). Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish. Journal of Genetics and Genomics 44, 567-576. (IF=4.275)

20) Zhan Yandong#, Huang Youkui#, Chen Jingying#, Cao Zigang, He Jianbo, Zhang Jingjing, Huang Honghui, Ruan Hua, Luo Lingfei*, and Li Li*. (2018). Caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish. Journal of Genetics and Genomics 45, 315-324. (IF=5.157)

21) Chen Jingying, He Jianbo, Li Li, Yang Deqin*, and Luo Lingfei*. (2016). Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Scientific Reports 6: 26608. (IF=4.379)

22) Zhang Ling & He Jianbo*. (2018). Progress of GATA6 in liver development. Yichuan 40, 22-32.

*：通讯作者或共同通讯；#：共同第一作者

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